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PubMed COVID-19 Clinical Care

14031 - 14040 of 44979 results found

Safety and immunogenicity of heterologous boosting with orally administered aerosolized bivalent adenovirus type-5 vectored COVID-19 vaccine and B.1.1.529 variant adenovirus type-5 vectored COVID-19 vaccine in adults 18 years and older: a randomized, d...

Date
Tuesday, November 07, 2023 - 4:00 AM
Description
Vaccination strategies that can induce a broad spectrum immune response are important to enhance protection against SARS-CoV-2 variants. We conducted a randomized, double-blind and parallel controlled trial to evaluate the safety and immunogenicity

Generation of focused drug molecule library using recurrent neural network

Date
Monday, November 06, 2023 - 4:00 AM
Description
CONTEXT: With the wide application of deep learning in drug research and development, de novo molecular design methods based on recurrent neural network (RNN) have strong advantages in drug molecule generation. The RNN model can be used to learn the

Immune imprinting and next-generation coronavirus vaccines

Date
Monday, November 06, 2023 - 4:00 AM
Description
Vaccines based on historical virus isolates provide limited protection from continuously evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill over between animals and humans. Despite repeated booster