Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core
Description
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion
