PubMed COVID-19 Clinical Care

A multi-institutional exploration of emergency medicine physicians' attitudes and behaviours on antibiotic use during the COVID-19 pandemic: a mixed-methods study

Wednesday, March 29, 2023 - 4:00 AM

CONCLUSIONS: Self-reported antibiotic prescribing rates decreased in the ED during the COVID-19 pandemic due to less pressure to prescribe antibiotics. The lessons and experiences learnt from the COVID-19 pandemic can be incorporated into public and

Association of the quantitative oral health status of patients with COVID-19 with their organ status and immunity: A single-centre observational study

Wednesday, March 29, 2023 - 4:00 AM

CONCLUSION: Poor oral health is an important risk factor for severe COVID-19 complications in patients admitted to an intensive care unit. The Oral Assessment Guide and resazurin disc test can evaluate oral conditions; however, the resazurin disc

Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells

Wednesday, March 29, 2023 - 4:00 AM

Curcumin has been reported to exert its anti-SARS-CoV-2 activity by inhibiting the binding of spike receptor-binding domain (RBD) to angiotensin-converting enzyme-2 (ACE2). To identify more potent compounds, we evaluated the antiviral activities of

Application of Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung and Trachea Exposure of Pyronaridine and Artesunate in Hamsters

Wednesday, March 29, 2023 - 4:00 AM

A fixed-dose combination of pyronaridine and artesunate, one of the artemisinin-based combination therapies, has been used as a potent antimalarial treatment regimen. Recently, several studies have reported the antiviral effects of both drugs against

A new gambler at the table of management of COVID-19 associated acute respiratory failure. Changing position to do it better?

Wednesday, March 29, 2023 - 4:00 AM

No abstract

A theoretical survey to find potential natural compound for inhibition of binding the RBD domain to ACE2 receptor based on plant antivirals

Tuesday, March 28, 2023 - 4:00 AM

The spike protein of coronavirus is crucial in binding and arrival of the virus to the human cell via binding to the human ACE2 receptor. In this study, at first 25 antiviral phytochemicals were docked into the RBD domain of spike protein, and then

Association of ACE ID, MTHFR C677T, and MIF-173GC variants with the clinical course of COVID-19 patients

Tuesday, March 28, 2023 - 4:00 AM

The course of coronavirus disease-2019 (COVID-19) differs from person to person. The relationship between the genetic variations of the host and the course of COVID-19 has been a matter of interest. In this study, we investigated whether Angiotensin

Amplitude Spectrum Area of ventricular fibrillation to guide defibrillation: a small open-label, pseudo-randomized controlled multicenter trial

Tuesday, March 28, 2023 - 4:00 AM

BACKGROUND: Ventricular fibrillation (VF) waveform analysis has been proposed as a potential non-invasive guide to optimize timing of defibrillation.

A pilot study: Validation of dried blood spots (DBS) to assess SARS-CoV2 IgG antibody immunoassays in underserved minority population

Tuesday, March 28, 2023 - 4:00 AM

Underserved, low-income, rural and certain migrant populations have greater risks and higher incidences of Coronavirus disease 2019 (COVID-19) than more privileged populations. Current in-person testing methods have limitations, namely exposure risk

Anxiety Among Correctional/Detention Health Professionals and Associated Risk Factors During the Coronavirus Disease 2019 Pandemic

Tuesday, March 28, 2023 - 4:00 AM

Correctional health professionals are vulnerable to the negative mental health outcomes associated with the coronavirus disease 2019 (COVID-19) pandemic. A cross-sectional survey was conducted to assess anxiety symptoms in health professionals who